BAIT
TOP3B
TOP3B1
topoisomerase (DNA) III beta
GO Process (0)
GO Function (2)
GO Component (2)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleoplasm [IDA]
- nucleus [IDA]
Homo sapiens
PREY
CDK5R1
CDK5P35, CDK5R, NCK5A, p23, p25, p35, p35nck5a
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
GO Process (19)
GO Function (7)
GO Component (15)
Gene Ontology Biological Process
- G-protein coupled acetylcholine receptor signaling pathway [ISS]
- axon guidance [ISS, TAS]
- axonal fasciculation [ISS]
- brain development [ISS, NAS]
- cell proliferation [TAS]
- ephrin receptor signaling pathway [ISS]
- ionotropic glutamate receptor signaling pathway [ISS]
- negative regulation of transcription, DNA-templated [IMP]
- neuron cell-cell adhesion [ISS]
- neuron differentiation [ISS]
- neuron migration [ISS]
- neuron projection development [ISS]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of neuron apoptotic process [ISS]
- positive regulation of protein serine/threonine kinase activity [IDA, ISS]
- regulation of cyclin-dependent protein serine/threonine kinase activity [TAS]
- regulation of dendritic spine morphogenesis [ISS]
- regulation of neuron differentiation [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- axon [ISS]
- contractile fiber [ISS]
- cytoplasm [ISS]
- cytosol [TAS]
- dendrite [ISS]
- dendritic spine [ISS]
- growth cone [ISS]
- intracellular membrane-bounded organelle [IDA]
- membrane [ISS]
- neuromuscular junction [ISS]
- neuronal cell body [ISS]
- nucleoplasm [IDA]
- nucleus [ISS]
- perinuclear region of cytoplasm [IDA]
- postsynaptic density [ISS]
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
A dual-activity topoisomerase complex regulates mRNA translation and turnover.
Topoisomerase 3? (TOP3B) and TDRD3 form a dual-activity topoisomerase complex that interacts with FMRP and can change the topology of both DNA and RNA. Here, we investigated the post-transcriptional influence of TOP3B and associated proteins on mRNA translation and turnover. First, we discovered that in human HCT116 colon cancer cells, knock-out (KO) of TOP3B had similar effects on mRNA turnover ... [more]
Nucleic Acids Res Jul. 08, 2022; 50(12);7013-7033 [Pubmed: 35748872]
Throughput
- High Throughput
Curated By
- BioGRID