BAIT
TOP3B
TOP3B1
topoisomerase (DNA) III beta
GO Process (0)
GO Function (2)
GO Component (2)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleoplasm [IDA]
- nucleus [IDA]
Homo sapiens
PREY
SRGAP2
ARHGAP34, FNBP2, SRGAP2A, SRGAP3, RP11-312O7.2
SLIT-ROBO Rho GTPase activating protein 2
GO Process (14)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
- actin filament severing [IDA]
- axon guidance [TAS]
- cell proliferation [IMP]
- dendritic spine development [IDA]
- extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration [ISS]
- filopodium assembly [IDA]
- lamellipodium assembly involved in ameboidal cell migration [IMP]
- negative regulation of cell death [IMP]
- negative regulation of neuron migration [IDA]
- neuron projection morphogenesis [ISS]
- positive regulation of Rac GTPase activity [IDA, IMP]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
- substrate adhesion-dependent cell spreading [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
A dual-activity topoisomerase complex regulates mRNA translation and turnover.
Topoisomerase 3? (TOP3B) and TDRD3 form a dual-activity topoisomerase complex that interacts with FMRP and can change the topology of both DNA and RNA. Here, we investigated the post-transcriptional influence of TOP3B and associated proteins on mRNA translation and turnover. First, we discovered that in human HCT116 colon cancer cells, knock-out (KO) of TOP3B had similar effects on mRNA turnover ... [more]
Nucleic Acids Res Jul. 08, 2022; 50(12);7013-7033 [Pubmed: 35748872]
Throughput
- High Throughput
Curated By
- BioGRID