BAIT
TOP3B
TOP3B1
topoisomerase (DNA) III beta
GO Process (0)
GO Function (2)
GO Component (2)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleoplasm [IDA]
- nucleus [IDA]
Homo sapiens
PREY
SYNJ1
INPP5G, PARK20
synaptojanin 1
GO Process (15)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- inositol phosphate dephosphorylation [ISS]
- inositol phosphate metabolic process [TAS]
- neurotransmitter transport [ISS]
- phosphate-containing compound metabolic process [TAS]
- phosphatidylinositol biosynthetic process [TAS]
- phosphatidylinositol dephosphorylation [ISS]
- phosphatidylinositol metabolic process [ISS]
- phospholipid metabolic process [TAS]
- positive regulation of synaptic vesicle uncoating [TAS]
- regulation of synaptic vesicle membrane organization [TAS]
- small molecule metabolic process [TAS]
- synaptic vesicle endocytosis [ISS]
- synaptic vesicle priming [ISS]
- synaptic vesicle transport [ISS]
- synaptic vesicle uncoating [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
A dual-activity topoisomerase complex regulates mRNA translation and turnover.
Topoisomerase 3? (TOP3B) and TDRD3 form a dual-activity topoisomerase complex that interacts with FMRP and can change the topology of both DNA and RNA. Here, we investigated the post-transcriptional influence of TOP3B and associated proteins on mRNA translation and turnover. First, we discovered that in human HCT116 colon cancer cells, knock-out (KO) of TOP3B had similar effects on mRNA turnover ... [more]
Nucleic Acids Res Jul. 08, 2022; 50(12);7013-7033 [Pubmed: 35748872]
Throughput
- High Throughput
Curated By
- BioGRID