BAIT
TOP3B
TOP3B1
topoisomerase (DNA) III beta
GO Process (0)
GO Function (2)
GO Component (2)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleoplasm [IDA]
- nucleus [IDA]
Homo sapiens
PREY
VAMP8
EDB, VAMP-8
vesicle-associated membrane protein 8
GO Process (13)
GO Function (3)
GO Component (15)
Gene Ontology Biological Process
- autophagic vacuole fusion [IMP]
- endocytosis [IBA]
- eosinophil degranulation [IMP]
- exocytosis [IBA]
- membrane organization [TAS]
- mucus secretion [IMP]
- negative regulation of secretion by cell [IDA]
- neutrophil degranulation [IMP]
- positive regulation of histamine secretion by mast cell [IMP]
- post-Golgi vesicle-mediated transport [TAS]
- regulation of protein localization to plasma membrane [IDA]
- vesicle fusion [IBA]
- viral entry into host cell [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- SNARE complex [IDA]
- azurophil granule membrane [IDA]
- cytoplasm [IDA]
- cytosol [IDA]
- early endosome [TAS]
- extracellular vesicular exosome [IDA]
- late endosome membrane [IDA]
- lysosomal membrane [IDA]
- membrane [IDA]
- mucin granule [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, TAS]
- recycling endosome [IDA]
- secretory granule membrane [IDA, TAS]
- vesicle [IDA]
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
A dual-activity topoisomerase complex regulates mRNA translation and turnover.
Topoisomerase 3? (TOP3B) and TDRD3 form a dual-activity topoisomerase complex that interacts with FMRP and can change the topology of both DNA and RNA. Here, we investigated the post-transcriptional influence of TOP3B and associated proteins on mRNA translation and turnover. First, we discovered that in human HCT116 colon cancer cells, knock-out (KO) of TOP3B had similar effects on mRNA turnover ... [more]
Nucleic Acids Res Jul. 08, 2022; 50(12);7013-7033 [Pubmed: 35748872]
Throughput
- High Throughput
Curated By
- BioGRID