Publication

FAM46C and FNDC3A Are Multiple Myeloma Tumor Suppressors That Act in Concert to Impair Clearing of Protein Aggregates and Autophagy.

Manfrini N, Mancino M, Miluzio A, Oliveto S, Balestra M, Calamita P, Alfieri R, Rossi RL, Sassoe-Pognetto M, Salio C, Cuomo A, Bonaldi T, Manfredi M, Marengo E, Ranzato E, Martinotti S, Cittaro D, Tonon G, Biffo S

Multiple myeloma is a plasma cell neoplasm characterized by the production of unfolded immunoglobulins, which cause endoplasmic reticulum (ER) stress and sensitivity to proteasome inhibition. The genomic landscape of multiple myeloma is characterized by the loss of several genes rarely mutated in other cancers that may underline specific weaknesses of multiple myeloma cells. One of these is FAM46C that is ... [more]

Throughput

• High Throughput

Additional Notes

• False discovery rate (FDR) of all peptide identifications was set to a maximum of 1%.
• LP-1 multiple myeloma cell line
• Statistically significant enriched proteins were filtered using a threshold setting for differential analysis where S0=1 and FDR=0.05 comparing IP-FAM46C versus mock experiments.

Curated By

• BioGRID