BAIT
BPH1
L000003507, YCR032W
Protein homologous to Chediak-Higashi syndrome and Beige proteins; both of which are implicated in disease syndromes in human and mouse, respectively, due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting
GO Process (3)
GO Function (0)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
PIB2
S000007475, YGL023C
Protein of unknown function; contains FYVE domain; similar to Fab1 and Vps27
GO Process (0)
GO Function (0)
GO Component (1)
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
The yeast LYST homolog Bph1 is a Rab5 effector and prevents Atg8 lipidation at endosomes.
Lysosomes mediate degradation of macromolecules to their precursors for cellular recycling. Additionally, lysosome-related organelles mediate cell type-specific functions. Chediak-Higashi syndrome is an autosomal, recessive disease, in which loss of the protein LYST causes defects in lysosomes and lysosome-related organelles. The molecular function of LYST, however, is largely unknown. Here, we dissected the function of the yeast LYST homolog, Bph1. We ... [more]
J Cell Sci Apr. 15, 2022; 135(8); [Pubmed: 35343566]
Throughput
- High Throughput
Additional Notes
- Table S2
Related interactions
Curated By
- BioGRID