BAIT
RAB11A
YL8
RAB11A, member RAS oncogene family
GO Process (24)
GO Function (7)
GO Component (12)
Gene Ontology Biological Process
- GTP catabolic process [IBA, IDA]
- Rab protein signal transduction [IBA]
- astral microtubule organization [IMP]
- cytokinesis [IMP]
- establishment of protein localization to membrane [IMP]
- establishment of protein localization to organelle [IMP]
- establishment of vesicle localization [IMP]
- exocytosis [IBA]
- exosomal secretion [IMP]
- intracellular protein transport [IBA]
- melanosome transport [IBA, ISS]
- mitotic metaphase plate congression [IMP]
- multivesicular body assembly [IMP]
- neuron projection development [IMP]
- plasma membrane to endosome transport [NAS]
- positive regulation of G2/M transition of mitotic cell cycle [IMP]
- positive regulation of epithelial cell migration [IMP]
- protein localization to plasma membrane [IDA]
- regulation of multivesicular body size [IMP]
- regulation of vesicle-mediated transport [IMP]
- spindle assembly involved in mitosis [IMP]
- transmembrane transport [TAS]
- vesicle-mediated transport [IDA]
- water transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cleavage furrow [IDA]
- cytoplasmic vesicle [IDA]
- cytoplasmic vesicle membrane [TAS]
- extracellular vesicular exosome [IDA]
- kinetochore microtubule [IDA]
- multivesicular body [IDA]
- phagocytic vesicle [IDA]
- protein complex [IDA]
- recycling endosome [IBA, IDA, ISS]
- spindle pole [IDA]
- trans-Golgi network [IDA]
- vesicle [IDA]
Homo sapiens
PREY
TTN
CMD1G, CMH9, CMPD4, EOMFC, HMERF, LGMD2J, MYLK5, TMD
titin
GO Process (20)
GO Function (15)
GO Component (8)
Gene Ontology Biological Process
- blood coagulation [TAS]
- cardiac muscle contraction [IMP]
- cardiac muscle fiber development [IMP]
- cardiac muscle hypertrophy [IMP]
- cardiac muscle tissue morphogenesis [IMP]
- cardiac myofibril assembly [IMP]
- detection of muscle stretch [TAS]
- mitotic chromosome condensation [IEP]
- muscle contraction [NAS, TAS]
- muscle filament sliding [TAS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- regulation of catalytic activity [IMP]
- regulation of protein kinase activity [IMP]
- response to calcium ion [IDA]
- sarcomere organization [IMP]
- sarcomerogenesis [IMP]
- skeletal muscle myosin thick filament assembly [IMP]
- skeletal muscle thin filament assembly [IMP]
- striated muscle contraction [TAS]
Gene Ontology Molecular Function- actin filament binding [IDA]
- actinin binding [IDA, IPI]
- calcium ion binding [IDA]
- calmodulin binding [IPI, TAS]
- enzyme binding [IPI]
- identical protein binding [IPI]
- muscle alpha-actinin binding [IPI]
- protease binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein self-association [IDA]
- protein serine/threonine kinase activity [IDA]
- structural constituent of muscle [IMP, TAS]
- structural molecule activity conferring elasticity [TAS]
- telethonin binding [IPI, ISS]
- actin filament binding [IDA]
- actinin binding [IDA, IPI]
- calcium ion binding [IDA]
- calmodulin binding [IPI, TAS]
- enzyme binding [IPI]
- identical protein binding [IPI]
- muscle alpha-actinin binding [IPI]
- protease binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein self-association [IDA]
- protein serine/threonine kinase activity [IDA]
- structural constituent of muscle [IMP, TAS]
- structural molecule activity conferring elasticity [TAS]
- telethonin binding [IPI, ISS]
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Proximity labelling identifies pro-migratory endocytic recycling cargo and machinery of the Rab4 and Rab11 families.
Endocytic recycling controls the return of internalised cargoes to the plasma membrane to coordinate their positioning, availability and downstream signalling. The Rab4 and Rab11 small GTPase families regulate distinct recycling routes, broadly classified as fast recycling from early endosomes (Rab4) and slow recycling from perinuclear recycling endosomes (Rab11), and both routes handle a broad range of overlapping cargoes to regulate ... [more]
J Cell Sci Jun. 15, 2023; 136(12); [Pubmed: 37232246]
Throughput
- High Throughput
Additional Notes
- BioID
- Greater than 2-fold enrichment, at least two unique peptides, in at least three of four repeats
- Prey protein is part of longlist
Curated By
- BioGRID