BAIT
RAB4A
HRES-1, HRES-1/RAB4, HRES1, RAB4
RAB4A, member RAS oncogene family
GO Process (6)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CYR61
CCN1, GIG1, IGFBP10
cysteine-rich, angiogenic inducer, 61
GO Process (14)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- anatomical structure morphogenesis [TAS]
- cell adhesion [IBA]
- cell proliferation [TAS]
- cell-cell signaling [IBA]
- negative regulation of cell death [IBA]
- positive regulation of BMP signaling pathway [IGI]
- positive regulation of cell migration [IDA]
- positive regulation of osteoblast differentiation [IDA]
- positive regulation of osteoblast proliferation [IDA]
- positive regulation of protein kinase activity [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of ERK1 and ERK2 cascade [IDA]
- wound healing, spreading of cells [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Proximity labelling identifies pro-migratory endocytic recycling cargo and machinery of the Rab4 and Rab11 families.
Endocytic recycling controls the return of internalised cargoes to the plasma membrane to coordinate their positioning, availability and downstream signalling. The Rab4 and Rab11 small GTPase families regulate distinct recycling routes, broadly classified as fast recycling from early endosomes (Rab4) and slow recycling from perinuclear recycling endosomes (Rab11), and both routes handle a broad range of overlapping cargoes to regulate ... [more]
J Cell Sci Jun. 15, 2023; 136(12); [Pubmed: 37232246]
Throughput
- High Throughput
Additional Notes
- BioID
- Greater than 2-fold enrichment, at least two unique peptides, in at least three of four repeats
- Prey protein is part of longlist
Curated By
- BioGRID