RAB4A
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
EMD
Gene Ontology Biological Process
- cellular response to growth factor stimulus [IMP]
- mitotic cell cycle [TAS]
- mitotic nuclear envelope disassembly [TAS]
- mitotic nuclear envelope reassembly [TAS]
- muscle contraction [TAS]
- muscle organ development [TAS]
- negative regulation of catenin import into nucleus [IMP]
- negative regulation of fibroblast proliferation [IMP]
- positive regulation of protein export from nucleus [IMP]
- regulation of canonical Wnt signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Proximity labelling identifies pro-migratory endocytic recycling cargo and machinery of the Rab4 and Rab11 families.
Endocytic recycling controls the return of internalised cargoes to the plasma membrane to coordinate their positioning, availability and downstream signalling. The Rab4 and Rab11 small GTPase families regulate distinct recycling routes, broadly classified as fast recycling from early endosomes (Rab4) and slow recycling from perinuclear recycling endosomes (Rab11), and both routes handle a broad range of overlapping cargoes to regulate ... [more]
Throughput
- High Throughput
Additional Notes
- BioID
- Greater than 2-fold enrichment, at least two unique peptides, in at least three of four repeats
- Prey protein is part of longlist
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RAB4A EMD | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | 8.32 | BioGRID | 3002328 |
Curated By
- BioGRID