BAIT
TRIM72
BC067209, MG53
tripartite motif-containing 72
GO Process (11)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- exocytosis [TAS]
- membrane budding [TAS]
- muscle organ development [IMP]
- muscle system process [IMP]
- negative regulation of insulin receptor signaling pathway [IDA]
- negative regulation of insulin-like growth factor receptor signaling pathway [IGI]
- negative regulation of myotube differentiation [IDA]
- plasma membrane repair [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]
- protein homooligomerization [IPI]
- protein ubiquitination [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CAMK2A
CaMKII, R74975, mKIAA0968
calcium/calmodulin-dependent protein kinase II alpha
GO Process (13)
GO Function (8)
GO Component (5)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IMP]
- calcium ion transport [IMP]
- ionotropic glutamate receptor signaling pathway [ISO]
- peptidyl-serine phosphorylation [IMP, ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of calcium ion transport [IMP]
- positive regulation of cardiac muscle cell apoptotic process [IMP]
- protein autophosphorylation [IMP, ISO]
- protein phosphorylation [IDA, ISO]
- regulation of mitochondrial membrane permeability involved in apoptotic process [IMP]
- regulation of neuronal synaptic plasticity [IMP]
- regulation of neurotransmitter secretion [IMP]
- response to ischemia [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Blocking MG53S255 Phosphorylation Protects Diabetic Heart From Ischemic Injury.
As an integral component of cell membrane repair machinery, MG53 (mitsugumin 53) is important for cardioprotection induced by ischemia preconditioning and postconditioning. However, it also impairs insulin signaling via its E3 ligase activity-mediated ubiquitination-dependent degradation of IR (insulin receptor) and IRS1 (insulin receptor substrate 1) and its myokine function-induced allosteric blockage of IR. Here, we sought to develop MG53 into ... [more]
Circ Res Dec. 02, 2022; 131(12);962-976 [Pubmed: 36337049]
Throughput
- Low Throughput
Curated By
- BioGRID