An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Blocking MG53S255 Phosphorylation Protects Diabetic Heart From Ischemic Injury.

Lv F, Wang Y, Shan D, Guo S, Chen G, Jin L, Zheng W, Feng H, Zeng X, Zhang S, Zhang Y, Hu X, Xiao RP

As an integral component of cell membrane repair machinery, MG53 (mitsugumin 53) is important for cardioprotection induced by ischemia preconditioning and postconditioning. However, it also impairs insulin signaling via its E3 ligase activity-mediated ubiquitination-dependent degradation of IR (insulin receptor) and IRS1 (insulin receptor substrate 1) and its myokine function-induced allosteric blockage of IR. Here, we sought to develop MG53 into ... [more]

Circ Res Dec. 02, 2022; 131(12);962-976 [Pubmed: 36337049]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

TRIM72

Gene Ontology Biological Process

Gene Ontology Molecular Function

phosphatidylserine binding [ISS]

Gene Ontology Cellular Component

PGK1