BAIT
OTULIN
FAM105B, GUM
OTU deubiquitinase with linear linkage specificity
GO Process (7)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
- canonical Wnt signaling pathway [ISS]
- innate immune response [IMP]
- negative regulation of NF-kappaB transcription factor activity [IDA, IMP]
- negative regulation of inflammatory response [IMP]
- nucleotide-binding oligomerization domain containing 2 signaling pathway [IMP]
- protein linear deubiquitination [IDA]
- sprouting angiogenesis [ISS]
Gene Ontology Molecular Function
Homo sapiens
PREY
ACOT8
HNAACTE, PTE-1, PTE-2, PTE1, PTE2, hACTE-III, hTE, RP3-337O18.2
acyl-CoA thioesterase 8
GO Process (10)
GO Function (5)
GO Component (1)
Gene Ontology Biological Process
- acyl-CoA metabolic process [IDA]
- alpha-linolenic acid metabolic process [TAS]
- bile acid biosynthetic process [TAS]
- bile acid metabolic process [TAS]
- cellular lipid metabolic process [TAS]
- dicarboxylic acid catabolic process [IDA]
- fatty acid beta-oxidation using acyl-CoA oxidase [TAS]
- peroxisome fission [IDA]
- small molecule metabolic process [TAS]
- unsaturated fatty acid metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- peroxisomal matrix [IDA, IMP, TAS]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF-?B to the nucleus.
Mitochondria are increasingly recognized as cellular hubs to orchestrate signaling pathways that regulate metabolism, redox homeostasis, and cell fate decisions. Recent research revealed a role of mitochondria also in innate immune signaling; however, the mechanisms of how mitochondria affect signal transduction are poorly understood. Here, we show that the NF-?B pathway activated by TNF employs mitochondria as a platform for ... [more]
EMBO J Dec. 15, 2022; 41(24);e112006 [Pubmed: 36398858]
Throughput
- High Throughput
Curated By
- BioGRID