BAIT
OTULIN
FAM105B, GUM
OTU deubiquitinase with linear linkage specificity
GO Process (7)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
- canonical Wnt signaling pathway [ISS]
- innate immune response [IMP]
- negative regulation of NF-kappaB transcription factor activity [IDA, IMP]
- negative regulation of inflammatory response [IMP]
- nucleotide-binding oligomerization domain containing 2 signaling pathway [IMP]
- protein linear deubiquitination [IDA]
- sprouting angiogenesis [ISS]
Gene Ontology Molecular Function
Homo sapiens
PREY
DNAJB1
HSPF1, Hdj1, Hsp40, RSPH16B, Sis1
DnaJ (Hsp40) homolog, subfamily B, member 1
GO Process (4)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF-?B to the nucleus.
Mitochondria are increasingly recognized as cellular hubs to orchestrate signaling pathways that regulate metabolism, redox homeostasis, and cell fate decisions. Recent research revealed a role of mitochondria also in innate immune signaling; however, the mechanisms of how mitochondria affect signal transduction are poorly understood. Here, we show that the NF-?B pathway activated by TNF employs mitochondria as a platform for ... [more]
EMBO J Dec. 15, 2022; 41(24);e112006 [Pubmed: 36398858]
Throughput
- High Throughput
Curated By
- BioGRID