BAIT
DVL2
dishevelled segment polarity protein 2
GO Process (16)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- Wnt signaling pathway [IGI]
- Wnt signaling pathway, planar cell polarity pathway [IDA]
- canonical Wnt signaling pathway [IDA]
- canonical Wnt signaling pathway involved in regulation of cell proliferation [IDA]
- heart development [ISS]
- hippo signaling [TAS]
- neural tube closure [ISS]
- non-canonical Wnt signaling pathway [IMP]
- outflow tract morphogenesis [ISS]
- planar cell polarity pathway involved in neural tube closure [IBA]
- positive regulation of JUN kinase activity [IDA, IMP]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- segment specification [ISS]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function
Homo sapiens
PREY
PLEKHA5
PEPP-2, PEPP2
pleckstrin homology domain containing, family A member 5
GO Process (0)
GO Function (2)
GO Component (1)
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Ubiquitin-assisted phase separation of dishevelled-2 promotes Wnt signalling.
Dishvelled-2 (Dvl2) is an essential component of Wnt pathway, which controls several cell fate decisions during development, such as proliferation, survival and differentiation. Dvl2 forms higher-order protein assemblies in the cell that are critical for relaying the signal from upstream Wnt ligand-frizzled receptor binding to downstream effector ?-catenin activation. However, the precise molecular nature and contribution of Dvl2 protein assemblies ... [more]
J Cell Sci Dec. 15, 2022; 135(24); [Pubmed: 36398662]
Throughput
- Low Throughput
Curated By
- BioGRID