BAIT
AKT1
Akt, PKB, PKB/Akt, PKBalpha, Rac
thymoma viral proto-oncogene 1
GO Process (82)
GO Function (15)
GO Component (12)
Gene Ontology Biological Process
- activation-induced cell death of T cells [ISO]
- aging [ISO]
- anagen [IMP]
- apoptotic mitochondrial changes [IDA]
- cell projection organization [ISO]
- cellular response to epidermal growth factor stimulus [IDA]
- cellular response to granulocyte macrophage colony-stimulating factor stimulus [IDA]
- cellular response to growth factor stimulus [IDA]
- cellular response to hypoxia [ISO]
- cellular response to insulin stimulus [IDA, IMP, ISO]
- cellular response to mechanical stimulus [ISO]
- cellular response to organic cyclic compound [ISO]
- cellular response to peptide [IDA]
- cellular response to prostaglandin E stimulus [IDA]
- cytoskeleton organization [TAS]
- execution phase of apoptosis [IDA]
- germ cell development [IDA]
- glucose homeostasis [IMP]
- glucose metabolic process [IMP]
- glucose transport [IMP]
- glycogen biosynthetic process [ISO]
- glycogen cell differentiation involved in embryonic placenta development [IMP]
- glycogen metabolic process [IMP]
- inflammatory response [IDA]
- insulin receptor signaling pathway [IMP, ISO]
- insulin-like growth factor receptor signaling pathway [ISO]
- intracellular signal transduction [ISO]
- labyrinthine layer blood vessel development [IMP]
- maternal placenta development [IMP]
- negative regulation of JNK cascade [ISO]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of autophagy [ISO]
- negative regulation of cell size [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- negative regulation of endopeptidase activity [ISO]
- negative regulation of fatty acid beta-oxidation [ISO]
- negative regulation of plasma membrane long-chain fatty acid transport [ISO]
- negative regulation of protein kinase activity [ISO]
- negative regulation of proteolysis [ISO]
- negative regulation of release of cytochrome c from mitochondria [IDA]
- osteoblast differentiation [IGI]
- peptidyl-serine phosphorylation [IDA, ISO]
- peripheral nervous system myelin maintenance [IMP]
- phosphorylation [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of blood vessel endothelial cell migration [ISO]
- positive regulation of cell growth [ISO]
- positive regulation of cellular protein metabolic process [ISO]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [ISO]
- positive regulation of endothelial cell proliferation [ISO]
- positive regulation of establishment of protein localization to plasma membrane [ISO]
- positive regulation of fat cell differentiation [ISO]
- positive regulation of glucose import [ISO]
- positive regulation of glucose metabolic process [ISO]
- positive regulation of glycogen biosynthetic process [ISO]
- positive regulation of lipid biosynthetic process [ISO]
- positive regulation of nitric oxide biosynthetic process [ISO]
- positive regulation of nitric-oxide synthase activity [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of sodium ion transport [IDA, IMP, ISO]
- positive regulation of transcription from RNA polymerase II promoter [IGI]
- positive regulation of vasoconstriction [ISO]
- protein catabolic process [IDA]
- protein import into nucleus, translocation [ISO]
- protein kinase B signaling [IGI]
- protein phosphorylation [IDA, ISO]
- protein ubiquitination [IDA]
- regulation of cell migration [ISO]
- regulation of glycogen biosynthetic process [ISO]
- regulation of myelination [IMP]
- regulation of neuron projection development [IDA]
- regulation of protein localization [IDA, ISO]
- response to UV-A [ISO]
- response to fluid shear stress [ISO]
- response to food [IDA]
- response to hormone [IDA]
- signal transduction [ISO]
- striated muscle cell differentiation [IGI]
- translation [ISO]
Gene Ontology Molecular Function- 14-3-3 protein binding [ISO]
- ATP binding [ISO]
- enzyme binding [ISO]
- identical protein binding [ISO]
- kinase activity [ISO]
- nitric-oxide synthase regulator activity [ISO]
- phosphatidylinositol-3,4,5-trisphosphate binding [ISO]
- phosphatidylinositol-3,4-bisphosphate binding [ISO]
- protein binding [IPI]
- protein kinase C binding [ISO]
- protein kinase activity [IDA, ISO]
- protein kinase binding [IPI]
- protein phosphatase 2A binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- protein serine/threonine/tyrosine kinase activity [ISO]
- 14-3-3 protein binding [ISO]
- ATP binding [ISO]
- enzyme binding [ISO]
- identical protein binding [ISO]
- kinase activity [ISO]
- nitric-oxide synthase regulator activity [ISO]
- phosphatidylinositol-3,4,5-trisphosphate binding [ISO]
- phosphatidylinositol-3,4-bisphosphate binding [ISO]
- protein binding [IPI]
- protein kinase C binding [ISO]
- protein kinase activity [IDA, ISO]
- protein kinase binding [IPI]
- protein phosphatase 2A binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- protein serine/threonine/tyrosine kinase activity [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
BAD
AI325008, Bbc2
BCL2-associated agonist of cell death
GO Process (39)
GO Function (9)
GO Component (5)
Gene Ontology Biological Process
- ADP metabolic process [IMP]
- ATP metabolic process [IMP]
- activation of cysteine-type endopeptidase activity [ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA, ISO]
- apoptotic process [ISO]
- apoptotic signaling pathway [IDA, IMP]
- cell proliferation [IDA]
- cellular process regulating host cell cycle in response to virus [IDA]
- cellular response to nicotine [ISO]
- cellular response to organic substance [ISO]
- cytokine-mediated signaling pathway [IDA]
- extrinsic apoptotic signaling pathway [ISO]
- extrinsic apoptotic signaling pathway in absence of ligand [IDA, IGI, IMP]
- extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- glucose catabolic process [IMP]
- glucose homeostasis [IMP]
- intrinsic apoptotic signaling pathway [ISO]
- intrinsic apoptotic signaling pathway in response to DNA damage [IDA, IMP]
- pore complex assembly [ISO]
- positive regulation of B cell differentiation [IMP]
- positive regulation of T cell differentiation [IMP]
- positive regulation of apoptotic process [IDA, ISO]
- positive regulation of apoptotic process by virus [IDA]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of glucokinase activity [IMP]
- positive regulation of insulin secretion [IMP]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [IMP]
- positive regulation of mitochondrial membrane potential [IMP]
- positive regulation of neuron death [ISO]
- positive regulation of proteolysis [ISO]
- positive regulation of release of cytochrome c from mitochondria [ISO]
- positive regulation of type B pancreatic cell development [IMP]
- regulation of apoptotic process [IDA]
- regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- regulation of mitochondrial membrane permeability [ISO]
- release of cytochrome c from mitochondria [IMP]
- suppression by virus of host apoptotic process [IDA, IMP]
- type B pancreatic cell proliferation [IMP]
Gene Ontology Molecular Function- cysteine-type endopeptidase activator activity involved in apoptotic process [IDA, ISO]
- lipid binding [ISO]
- phospholipid binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein kinase B binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase 2B binding [ISO]
- protein phosphatase binding [IPI]
- cysteine-type endopeptidase activator activity involved in apoptotic process [IDA, ISO]
- lipid binding [ISO]
- phospholipid binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein kinase B binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase 2B binding [ISO]
- protein phosphatase binding [IPI]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Akt Phosphorylation Orchestrates T11TS Mediated Cell Cycle Arrest in Glioma Cells.
The novel anti-neoplastic glycopeptide T11TS retards glioma both in in-vitro clinical samples and in-vivo models. This study investigates the correlation between altering the glioma microenvironment with glioma arrest and death. Flow cytometry, immunoblotting, ELISA, and co-immunoprecipitation were employed to investigate glioma cell arrest and death. Results include a decline in phosphorylation of Akt and attenuation of p21 phosphorylation (Thr145,Ser146) and ... [more]
Cancer Invest Nov. 01, 2021; 39(10);854-870 [Pubmed: 34569407]
Throughput
- Low Throughput
Curated By
- BioGRID