FBXO3
Gene Ontology Cellular Component
HIPK2
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [ISO]
- SMAD protein signal transduction [ISO]
- adult locomotory behavior [IMP]
- adult walking behavior [IMP]
- anterior/posterior pattern specification [IGI]
- embryonic camera-type eye morphogenesis [IMP]
- embryonic retina morphogenesis in camera-type eye [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IGI]
- iris morphogenesis [IMP]
- lens induction in camera-type eye [IMP]
- negative regulation of BMP signaling pathway [ISO]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of nucleic acid-templated transcription [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- neuron differentiation [IMP]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of DNA binding [IDA]
- positive regulation of JNK cascade [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of cell proliferation [IGI]
- positive regulation of protein binding [IDA]
- positive regulation of protein phosphorylation [IGI]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IGI, IMP]
- positive regulation of transcription, DNA-templated [ISO]
- positive regulation of transforming growth factor beta receptor signaling pathway [ISO]
- protein phosphorylation [IDA, ISA, ISO]
- retina layer formation [IMP]
- smoothened signaling pathway [IGI]
- transforming growth factor beta receptor signaling pathway [IMP]
- voluntary musculoskeletal movement [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II transcription coactivator activity [IMP]
- SMAD binding [ISO]
- protein binding [IPI]
- protein kinase activity [IDA, ISO]
- protein serine/threonine kinase activity [IDA, ISA]
- transcription corepressor activity [IDA, ISO]
- virion binding [ISO]
- DNA binding [IDA]
- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II transcription coactivator activity [IMP]
- SMAD binding [ISO]
- protein binding [IPI]
- protein kinase activity [IDA, ISO]
- protein serine/threonine kinase activity [IDA, ISA]
- transcription corepressor activity [IDA, ISO]
- virion binding [ISO]
Gene Ontology Cellular Component
- PML body [ISO, TAS]
- cytoplasm [IDA]
- intracellular [IGI]
- nuclear body [ISO]
- nucleus [IDA, ISO]
- protein complex [IMP]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
E3 Ubiquitin Ligase FBXO3 Drives Neuroinflammation to Aggravate Cerebral Ischemia/Reperfusion Injury.
Ischemic stroke, one of the most universal causes of human mortality and morbidity, is pathologically characterized by inflammatory cascade, especially during the progression of ischemia/reperfusion (I/R) injury. F-Box Protein 3 (FBXO3), a substrate-recognition subunit of SKP1-cullin 1-F-box protein (SCF) E3 ligase complexes, has recently been proven to be severed as an underlying pro-inflammatory factor in pathological processes of diverse diseases. ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID