An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

Publication

PTP4A2 promotes lysophagy by dephosphorylation of VCP/p97 at Tyr805.

Bai Y, Yu G, Zhou HM, Amarasinghe O, Zhou Y, Zhu P, Li Q, Zhang L, Nguele Meke F, Miao Y, Chapman E, Tao WA, Zhang ZY

Overexpression of PTP4A phosphatases are associated with advanced cancers, but their biological functions are far from fully understood due to limited knowledge about their physiological substrates. VCP is implicated in lysophagy via collaboration with specific cofactors in the ELDR complex. However, how the ELDR complex assembly is regulated has not been determined. Moreover, the functional significance of the penultimate and ... [more]

Autophagy May. 01, 2023; 19(5);1562-1581 [Pubmed: 36300783]

Throughput

High Throughput

Curated By

BioGRID

Interaction Summary

PTP4A2

Gene Ontology Biological Process

Gene Ontology Molecular Function

prenylated protein tyrosine phosphatase activity [TAS]

Gene Ontology Cellular Component

STXBP1