BAIT
CST1
cystatin SN
GO Process (2)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
PREY
LGMN
AEP, LGMN1, PRSC1
legumain
GO Process (12)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- innate immune response [TAS]
- negative regulation of ERBB signaling pathway [ISS]
- negative regulation of neuron apoptotic process [IGI]
- proteolysis [ISS]
- proteolysis involved in cellular protein catabolic process [ISS]
- receptor catabolic process [ISS]
- renal system process [ISS]
- small molecule metabolic process [TAS]
- steroid metabolic process [TAS]
- toll-like receptor signaling pathway [TAS]
- vitamin D metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
CST1 inhibits ferroptosis and promotes gastric cancer metastasis by regulating GPX4 protein stability via OTUB1.
Metastasis is an important factor contributing to poor prognosis in patients with gastric cancer; yet, the molecular mechanism leading to this cell behavior is still not well understood. In this study, we explored the role of cysteine protease inhibitor SN (Cystatin SN, CST1) in promoting gastric cancer metastasis. We hypothesized that CST1 could regulate gastric cancer progression by regulating GPX4 ... [more]
Oncogene Jan. 01, 2023; 42(2);83-98 [Pubmed: 36369321]
Throughput
- High Throughput
Curated By
- BioGRID