MOB1B
Gene Ontology Biological Process
Gene Ontology Molecular Function
DOCK7
Gene Ontology Biological Process
- activation of Rac GTPase activity [IDA]
- axonogenesis [IMP]
- establishment of neuroblast polarity [IMP]
- interkinetic nuclear migration [ISS]
- microtubule cytoskeleton organization [IMP]
- neuron projection development [IMP]
- positive regulation of peptidyl-serine phosphorylation [IMP]
- regulation of neurogenesis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.
Distinct functions mediated by members of the monopolar spindle-one-binder (MOB) family of proteins remain elusive beyond the evolutionarily conserved and well-established roles of MOB1 (MOB1A/B) in regulating tissue homeostasis within the Hippo pathway. Since MOB proteins are adaptors, understanding how they engage in protein-protein interactions, and help assemble complexes is essential to define the full scope of their biological functions. ... [more]
Throughput
- High Throughput
Additional Notes
- BFDR less than or equal to 0.01
- BioID
- Experiment performed in HEK293 cells
- Experiment performed in Hela cells
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MOB1B DOCK7 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | - | |
| MOB1B DOCK7 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9997 | BioGRID | 2229061 | |
| MOB1B DOCK7 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.997 | BioGRID | 3087255 |
Curated By
- BioGRID