BAIT

MOB2

HCCA2
MOB kinase activator 2
GO Process (0)
GO Function (0)
GO Component (3)

Gene Ontology Cellular Component

Homo sapiens
PREY

FARP1

CDEP, FARP1-IT1, PLEKHC2, PPP1R75, RP11-111L24.1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
Homo sapiens

Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

Publication

Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.

Elkholi IE, Boulais J, Thibault MP, Phan HD, Robert A, Lai LB, Faubert D, Smith MJ, Gopalan V, Cote JF

Distinct functions mediated by members of the monopolar spindle-one-binder (MOB) family of proteins remain elusive beyond the evolutionarily conserved and well-established roles of MOB1 (MOB1A/B) in regulating tissue homeostasis within the Hippo pathway. Since MOB proteins are adaptors, understanding how they engage in protein-protein interactions, and help assemble complexes is essential to define the full scope of their biological functions. ... [more]

J Biol Chem Aug. 01, 2023; ();105123 [Pubmed: 37536630]

Throughput

  • High Throughput

Additional Notes

  • BFDR less than or equal to 0.01
  • BioID
  • Experiment performed in Hela cells

Curated By

  • BioGRID