BAIT
PPM1B
PP2C-beta, PP2C-beta-X, PP2CB, PP2CBETA, PPC2BETAX
protein phosphatase, Mg2+/Mn2+ dependent, 1B
GO Process (8)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- N-terminal protein myristoylation [ISS]
- cytokine-mediated signaling pathway [TAS]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- negative regulation of NF-kappaB import into nucleus [IMP]
- negative regulation of defense response to virus [IMP]
- negative regulation of interferon-beta production [IMP]
- peptidyl-threonine dephosphorylation [IDA]
- protein dephosphorylation [IMP]
Gene Ontology Molecular Function
Homo sapiens
PREY
RPL34
L34
ribosomal protein L34
GO Process (13)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- SRP-dependent cotranslational protein targeting to membrane [TAS]
- cellular protein metabolic process [TAS]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [TAS]
- translation [NAS, TAS]
- translational elongation [TAS]
- translational initiation [TAS]
- translational termination [TAS]
- viral life cycle [TAS]
- viral process [TAS]
- viral transcription [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
TXLNA enhances TBK1 phosphorylation by suppressing PPM1B recruitment.
In recent years, there has been a notable increase in cancer incidence and mortality, and immune abnormalities have been closely linked to malignancy development. TANK-binding kinase 1 (TBK1) is a non-classical I?B kinase that regulates interferon and NF-?B signaling pathways and plays a crucial role in innate immunity. Recent studies have shown high expression levels of TBK1 and increased activity ... [more]
Biochim Biophys Acta Mol Cell Res Oct. 01, 2023; 1870(7);119550 [Pubmed: 37506885]
Throughput
- High Throughput
Additional Notes
- APEX2 proximity labeling
- Significance threshold of p < 0.01 and a fold change >1
Curated By
- BioGRID