OTULIN
Gene Ontology Biological Process
- canonical Wnt signaling pathway [ISS]
- innate immune response [IMP]
- negative regulation of NF-kappaB transcription factor activity [IDA, IMP]
- negative regulation of inflammatory response [IMP]
- nucleotide-binding oligomerization domain containing 2 signaling pathway [IMP]
- protein linear deubiquitination [IDA]
- sprouting angiogenesis [ISS]
Gene Ontology Molecular Function
TUBA1A
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
An interaction between OTULIN and SCRIB uncovers roles for linear ubiquitination in planar cell polarity.
Planar cell polarity (PCP) plays critical roles in developmental and homeostatic processes. Membrane presentation of PCP complexes containing Van Gogh-like (VANGL) transmembrane proteins is central to PCP and can be directed by the scaffold protein scribble (SCRIB). The role atypical linear ubiquitin (Met1-Ub) chains might play in PCP is unknown. Here, HEK293 cell-based interactomic analyses of the Met1-Ub deubiquitinase OTULIN ... [more]
Throughput
- High Throughput
Additional Notes
- High confidence interactors met a SAINT threshold > 0.8 in the AP-MS analysis of at least one FLAG-tagged OTULIN cell line.
- OTULIN W96R construct
- Wild type OTULIN
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| OTULIN TUBA1A | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.3874 | BioGRID | 3238624 |
Curated By
- BioGRID