BAIT
OTULIN
FAM105B, GUM
OTU deubiquitinase with linear linkage specificity
GO Process (7)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
- canonical Wnt signaling pathway [ISS]
- innate immune response [IMP]
- negative regulation of NF-kappaB transcription factor activity [IDA, IMP]
- negative regulation of inflammatory response [IMP]
- nucleotide-binding oligomerization domain containing 2 signaling pathway [IMP]
- protein linear deubiquitination [IDA]
- sprouting angiogenesis [ISS]
Gene Ontology Molecular Function
Homo sapiens
PREY
EIF4A2
BM-010, DDX2B, EIF4A, EIF4F, eIF-4A-II, eIF4A-II
eukaryotic translation initiation factor 4A2
GO Process (12)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- RNA metabolic process [TAS]
- cellular protein metabolic process [TAS]
- cytokine-mediated signaling pathway [TAS]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- negative regulation of RNA-directed RNA polymerase activity [IDA]
- nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [TAS]
- nuclear-transcribed mRNA poly(A) tail shortening [TAS]
- regulation of translational initiation [TAS]
- translation [TAS]
- translational initiation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
An interaction between OTULIN and SCRIB uncovers roles for linear ubiquitination in planar cell polarity.
Planar cell polarity (PCP) plays critical roles in developmental and homeostatic processes. Membrane presentation of PCP complexes containing Van Gogh-like (VANGL) transmembrane proteins is central to PCP and can be directed by the scaffold protein scribble (SCRIB). The role atypical linear ubiquitin (Met1-Ub) chains might play in PCP is unknown. Here, HEK293 cell-based interactomic analyses of the Met1-Ub deubiquitinase OTULIN ... [more]
Dis Model Mech Aug. 01, 2023; 16(8); [Pubmed: 37589075]
Throughput
- High Throughput
Additional Notes
- High confidence interactors met a SAINT threshold > 0.8 in the AP-MS analysis of at least one FLAG-tagged OTULIN cell line.
- OTULIN delta-PBM construct
Curated By
- BioGRID