BAIT
PPP1R14B
PHI-1, PLCB3N, PNG, SOM172
protein phosphatase 1, regulatory (inhibitor) subunit 14B
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
RAP1B
K-REV, RAL1B, OK/SW-cl.11
RAP1B, member of RAS oncogene family
GO Process (10)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
- Rap protein signal transduction [IMP]
- blood coagulation [TAS]
- cellular response to cAMP [IDA]
- energy reserve metabolic process [TAS]
- establishment of endothelial barrier [IMP]
- platelet activation [TAS]
- regulation of cell junction assembly [IMP]
- regulation of establishment of cell polarity [IMP]
- regulation of insulin secretion [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Protein Phosphatase 1 Subunit PPP1R14B Stabilizes STMN1 to Promote Progression and Paclitaxel Resistance in Triple-Negative Breast Cancer.
Triple-negative breast cancer (TNBC) represents the most lethal subtype of breast cancer due to its aggressive clinical features and the lack of effective therapeutic targets. To identify novel approaches for targeting TNBC, we examined the role of protein phosphatases in TNBC progression and chemoresistance. Protein phosphatase 1 regulatory subunit 14B (PPP1R14B), a poorly defined member of the protein phosphatase 1 ... [more]
Cancer Res Feb. 03, 2023; 83(3);471-484 [Pubmed: 36484700]
Throughput
- High Throughput
Curated By
- BioGRID