Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

Publication

?-catenin interaction with YAP/FoxM1/TEAD-induced CEP55 supports liver cancer cell migration.

Tang Y, Thiess L, Weiler SME, Toth M, Rose F, Merker S, Ruppert T, Schirmacher P, Breuhahn K

Adherens junctions (AJs) facilitate cell-cell contact and contribute to cellular communication as well as signaling under physiological and pathological conditions. Aberrant expression of AJ proteins is frequently observed in human cancers; however, how these factors contribute to tumorigenesis is poorly understood. In addition, for some factors such as ?-catenin contradicting data has been described. In this study we aim to ... [more]

Cell Commun Signal Jun. 28, 2023; 21(1);162 [Pubmed: 37381005]

Throughput

  • Low Throughput

Additional Notes

  • BioID

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
CTNNA1 NAP1L1
Proximity Label-MS
Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

High4.05BioGRID
2984749

Curated By

  • BioGRID