An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

Publication

?-catenin interaction with YAP/FoxM1/TEAD-induced CEP55 supports liver cancer cell migration.

Tang Y, Thiess L, Weiler SME, Toth M, Rose F, Merker S, Ruppert T, Schirmacher P, Breuhahn K

Adherens junctions (AJs) facilitate cell-cell contact and contribute to cellular communication as well as signaling under physiological and pathological conditions. Aberrant expression of AJ proteins is frequently observed in human cancers; however, how these factors contribute to tumorigenesis is poorly understood. In addition, for some factors such as ?-catenin contradicting data has been described. In this study we aim to ... [more]

Cell Commun Signal Jun. 28, 2023; 21(1);162 [Pubmed: 37381005]

Throughput

Low Throughput

Additional Notes

BioID

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
CTNNA1 SPTBN1	Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro.	Pradhan D (2001)	Low	-	BioGRID	-

Curated By

BioGRID

Interaction Summary

CTNNA1

Gene Ontology Biological Process

Gene Ontology Molecular Function

beta-catenin binding [IPI]cadherin binding [IPI]gamma-catenin binding [IPI]poly(A) RNA binding [IDA]protein binding [IPI]vinculin binding [IPI]

Gene Ontology Cellular Component

SPTBN1

Gene Ontology Biological Process

Gene Ontology Molecular Function

ankyrin binding [IPI, NAS]poly(A) RNA binding [IDA]protein binding [IPI]structural constituent of cytoskeleton [IMP]