LAIR1
Gene Ontology Molecular Function
Gene Ontology Cellular Component
COL1A1
Gene Ontology Biological Process
- blood coagulation [TAS]
- blood vessel development [IMP]
- collagen biosynthetic process [IMP]
- collagen catabolic process [TAS]
- collagen fibril organization [IMP]
- embryonic skeletal system development [IMP]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- leukocyte migration [TAS]
- platelet activation [TAS]
- positive regulation of canonical Wnt signaling pathway [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of epithelial to mesenchymal transition [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein localization to nucleus [IDA]
- sensory perception of sound [IMP]
- skeletal system development [IMP]
- skin morphogenesis [IMP]
- tooth mineralization [IMP]
- visual perception [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Polymerized type I collagen down-regulates STAT-1 phosphorylation through engagement to LAIR-1 in M1-macrophages avoiding long COVID
BackgroundThe polymerized type I collagen (PTIC) is a {gamma}-irradiated mixture of pepsinized porcine type I collagen and polyvinylpyrrolidone (PVP). It has immunomodulatory properties. However, the receptor and signaling pathway through which it exerts its therapeutic effects has not yet been identified.AimTo evaluate LAIR-1 as a potential receptor for PTIC and the signaling pathway evoked by ligand-receptor binding.MethodsLAIR-1 binding assay was ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID