SGO1
Gene Ontology Biological Process
- centromere complex assembly [IMP]
- establishment of protein localization [IDA]
- establishment of protein localization to chromosome [IMP]
- kinetochore organization [IDA, IMP]
- maintenance of meiotic sister chromatid cohesion [IMP]
- meiotic sister chromatid segregation [IMP]
- meiotic sister chromatid separation [IMP]
- mitotic sister chromatid segregation [IGI, IMP]
- mitotic spindle assembly checkpoint [IGI, IMP]
- positive regulation of maintenance of meiotic sister chromatid cohesion [IGI, IMP]
- sister chromatid biorientation [IMP]
Gene Ontology Cellular Component
SMC2
Gene Ontology Biological Process
- meiotic chromosome condensation [IC]
- meiotic chromosome separation [IC]
- mitotic chromosome condensation [IMP]
- mitotic sister chromatid segregation [IMP]
- negative regulation of meiotic DNA double-strand break formation [IMP]
- rDNA condensation [IMP]
- synaptonemal complex assembly [IC]
- tRNA gene clustering [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
SUMOylation stabilizes sister kinetochore biorientation to allow timely anaphase.
During mitosis, sister chromatids attach to microtubules from opposite poles, called biorientation. Sister chromatid cohesion resists microtubule forces, generating tension, which provides the signal that biorientation has occurred. How tension silences the surveillance pathways that prevent cell cycle progression and correct erroneous kinetochore-microtubule attachments remains unclear. Here we show that SUMOylation dampens error correction to allow stable sister kinetochore biorientation ... [more]
Throughput
- High Throughput
Additional Notes
- Co-IP with Sgo1-4R or Sgo1
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SGO1 SMC2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 948850 | |
| SMC2 SGO1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| SGO1 SMC2 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| SMC2 SGO1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 352880 |
Curated By
- BioGRID