BAIT

TGOLN2

TGN38, TGN46, TGN48, TGN51, TTGN2
trans-golgi network protein 2
GO Process (0)
GO Function (1)
GO Component (4)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

ITGA5

CD49e, FNRA, VLA5A
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
Homo sapiens

Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

Publication

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

Simonetti B, Daly JL, Simon-Gracia L, Klein K, Weeratunga S, Anton-Plagaro C, Tobi A, Hodgson L, Lewis PA, Heesom KJ, Shoemark DK, Davidson AD, Collins BM, Teesalu T, Yamauchi Y, Cullen PJ

Endosomal sorting maintains cellular homeostasis by recycling transmembrane proteins and associated proteins and lipids (termed "cargoes") from the endosomal network to multiple subcellular destinations, including retrograde traffic to the trans-Golgi network (TGN). Viral and bacterial pathogens subvert retrograde trafficking machinery to facilitate infectivity. Here, we develop a proteomic screen to identify retrograde cargo proteins of the endosomal SNX-BAR sorting complex ... [more]

Proc Natl Acad Sci U S A Jun. 21, 2022; 119(25);e2201980119 [Pubmed: 35696571]

Throughput

  • High Throughput|Low Throughput

Additional Notes

  • LTP hit ID'd by western

Curated By

  • BioGRID