BAIT
TGOLN2
TGN38, TGN46, TGN48, TGN51, TTGN2
trans-golgi network protein 2
GO Process (0)
GO Function (1)
GO Component (4)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TMED10
P24(DELTA), S31I125, S31III125, TMP21, Tmp-21-I, p23
transmembrane emp24-like trafficking protein 10 (yeast)
GO Process (10)
GO Function (2)
GO Component (13)
Gene Ontology Biological Process
- COPI coating of Golgi vesicle [TAS]
- COPI-coated vesicle budding [IDA]
- COPII vesicle coating [TAS]
- ER to Golgi vesicle-mediated transport [TAS]
- cargo loading into vesicle [TAS]
- intracellular protein transport [IDA]
- regulated secretory pathway [ISS]
- regulation of beta-amyloid formation [IMP]
- retrograde vesicle-mediated transport, Golgi to ER [ISS]
- vesicle targeting, to, from or within Golgi [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- COPI-coated vesicle [ISS]
- Golgi apparatus [IDA]
- Golgi membrane [IDA, TAS]
- cis-Golgi network [ISS]
- endoplasmic reticulum [IDA]
- endoplasmic reticulum-Golgi intermediate compartment [IDA]
- extracellular vesicular exosome [IDA]
- gamma-secretase complex [IDA]
- integral component of membrane [ISS]
- plasma membrane [ISS]
- secretory granule membrane [ISS]
- trans-Golgi network transport vesicle [ISS]
- zymogen granule membrane [ISS]
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.
Endosomal sorting maintains cellular homeostasis by recycling transmembrane proteins and associated proteins and lipids (termed "cargoes") from the endosomal network to multiple subcellular destinations, including retrograde traffic to the trans-Golgi network (TGN). Viral and bacterial pathogens subvert retrograde trafficking machinery to facilitate infectivity. Here, we develop a proteomic screen to identify retrograde cargo proteins of the endosomal SNX-BAR sorting complex ... [more]
Proc Natl Acad Sci U S A Jun. 21, 2022; 119(25);e2201980119 [Pubmed: 35696571]
Throughput
- High Throughput
Curated By
- BioGRID