BAIT
TGOLN2
TGN38, TGN46, TGN48, TGN51, TTGN2
trans-golgi network protein 2
GO Process (0)
GO Function (1)
GO Component (4)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GBA
GBA1, GCB, GLUC
glucosidase, beta, acid
GO Process (12)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- cellular response to tumor necrosis factor [IMP]
- ceramide biosynthetic process [IMP]
- glucosylceramide catabolic process [IMP]
- glycosphingolipid metabolic process [TAS]
- negative regulation of MAP kinase activity [IMP]
- negative regulation of inflammatory response [IC]
- negative regulation of interleukin-6 production [IDA]
- positive regulation of protein dephosphorylation [IMP]
- small molecule metabolic process [TAS]
- sphingolipid metabolic process [TAS]
- sphingosine biosynthetic process [IMP]
- termination of signal transduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.
Endosomal sorting maintains cellular homeostasis by recycling transmembrane proteins and associated proteins and lipids (termed "cargoes") from the endosomal network to multiple subcellular destinations, including retrograde traffic to the trans-Golgi network (TGN). Viral and bacterial pathogens subvert retrograde trafficking machinery to facilitate infectivity. Here, we develop a proteomic screen to identify retrograde cargo proteins of the endosomal SNX-BAR sorting complex ... [more]
Proc Natl Acad Sci U S A Jun. 21, 2022; 119(25);e2201980119 [Pubmed: 35696571]
Throughput
- High Throughput
Curated By
- BioGRID