BAIT
TGOLN2
TGN38, TGN46, TGN48, TGN51, TTGN2
trans-golgi network protein 2
GO Process (0)
GO Function (1)
GO Component (4)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SERPINE2
GDN, GDNPF, PI-7, PI7, PN-1, PN1, PNI
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
GO Process (8)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
- negative regulation of blood coagulation [IC, IDA]
- negative regulation of endopeptidase activity [IBA]
- negative regulation of plasminogen activation [IMP]
- negative regulation of platelet aggregation [ISS]
- negative regulation of protein processing [IC]
- negative regulation of proteolysis [IDA]
- positive regulation of astrocyte differentiation [IDA]
- regulation of cell migration [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.
Endosomal sorting maintains cellular homeostasis by recycling transmembrane proteins and associated proteins and lipids (termed "cargoes") from the endosomal network to multiple subcellular destinations, including retrograde traffic to the trans-Golgi network (TGN). Viral and bacterial pathogens subvert retrograde trafficking machinery to facilitate infectivity. Here, we develop a proteomic screen to identify retrograde cargo proteins of the endosomal SNX-BAR sorting complex ... [more]
Proc Natl Acad Sci U S A Jun. 21, 2022; 119(25);e2201980119 [Pubmed: 35696571]
Throughput
- High Throughput
Curated By
- BioGRID