BAIT
TGOLN2
TGN38, TGN46, TGN48, TGN51, TTGN2
trans-golgi network protein 2
GO Process (0)
GO Function (1)
GO Component (4)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SERPINE1
PAI, PAI-1, PAI1, PLANH1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
GO Process (34)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- angiogenesis [IEP]
- blood coagulation [TAS]
- cellular response to lipopolysaccharide [IMP]
- chronological cell aging [IEP]
- defense response to Gram-negative bacterium [IGI]
- extracellular matrix organization [TAS]
- fibrinolysis [TAS]
- gene expression [TAS]
- negative regulation of blood coagulation [IC]
- negative regulation of cell adhesion mediated by integrin [IDA]
- negative regulation of cell migration [IDA]
- negative regulation of endopeptidase activity [IDA]
- negative regulation of endothelial cell apoptotic process [IMP]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- negative regulation of fibrinolysis [IDA]
- negative regulation of plasminogen activation [IDA, IMP]
- negative regulation of smooth muscle cell migration [IDA]
- negative regulation of smooth muscle cell-matrix adhesion [IDA]
- negative regulation of vascular wound healing [IGI]
- negative regulation of wound healing [IC]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of angiogenesis [IMP]
- positive regulation of blood coagulation [IMP]
- positive regulation of inflammatory response [IGI]
- positive regulation of interleukin-8 production [IMP]
- positive regulation of leukotriene production involved in inflammatory response [IMP]
- positive regulation of monocyte chemotaxis [IMP]
- positive regulation of receptor-mediated endocytosis [IDA]
- positive regulation of transcription from RNA polymerase II promoter [TAS]
- regulation of receptor activity [IDA]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.
Endosomal sorting maintains cellular homeostasis by recycling transmembrane proteins and associated proteins and lipids (termed "cargoes") from the endosomal network to multiple subcellular destinations, including retrograde traffic to the trans-Golgi network (TGN). Viral and bacterial pathogens subvert retrograde trafficking machinery to facilitate infectivity. Here, we develop a proteomic screen to identify retrograde cargo proteins of the endosomal SNX-BAR sorting complex ... [more]
Proc Natl Acad Sci U S A Jun. 21, 2022; 119(25);e2201980119 [Pubmed: 35696571]
Throughput
- High Throughput
Curated By
- BioGRID