BAIT
TGOLN2
TGN38, TGN46, TGN48, TGN51, TTGN2
trans-golgi network protein 2
GO Process (0)
GO Function (1)
GO Component (4)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CLU
APO-J, APOJ, CLI, CLU1, CLU2, KUB1, NA1/NA2, SGP-2, SGP2, SP-40, TRPM-2, TRPM2, AAG4
clusterin
GO Process (35)
GO Function (4)
GO Component (12)
Gene Ontology Biological Process
- blood coagulation [TAS]
- cell morphogenesis [IDA]
- central nervous system myelin maintenance [IMP]
- chaperone-mediated protein complex assembly [IDA]
- chaperone-mediated protein folding [IDA]
- complement activation [TAS]
- intrinsic apoptotic signaling pathway [IDA]
- lipid metabolic process [NAS]
- microglial cell activation [IDA]
- microglial cell proliferation [IDA]
- negative regulation of beta-amyloid formation [IDA]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [IMP]
- negative regulation of protein homooligomerization [IMP]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of beta-amyloid formation [ISS]
- positive regulation of intrinsic apoptotic signaling pathway [IMP]
- positive regulation of neurofibrillary tangle assembly [IMP]
- positive regulation of neuron death [IDA, IMP]
- positive regulation of nitric oxide biosynthetic process [IDA]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of tau-protein kinase activity [IMP]
- positive regulation of tumor necrosis factor production [IDA]
- protein import [IDA]
- protein stabilization [IDA]
- regulation of beta-amyloid clearance [IDA]
- regulation of neuron death [IDA, IMP]
- regulation of neuronal signal transduction [IMP]
- release of cytochrome c from mitochondria [IC]
- response to misfolded protein [IDA]
- response to virus [IEP]
- reverse cholesterol transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- apical dendrite [IDA]
- blood microparticle [IDA]
- cytoplasm [IDA]
- extracellular matrix [IDA]
- extracellular region [TAS]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- mitochondrion [IDA]
- neurofibrillary tangle [IDA]
- perinuclear region of cytoplasm [IDA]
- platelet alpha granule lumen [TAS]
- spherical high-density lipoprotein particle [IDA]
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.
Endosomal sorting maintains cellular homeostasis by recycling transmembrane proteins and associated proteins and lipids (termed "cargoes") from the endosomal network to multiple subcellular destinations, including retrograde traffic to the trans-Golgi network (TGN). Viral and bacterial pathogens subvert retrograde trafficking machinery to facilitate infectivity. Here, we develop a proteomic screen to identify retrograde cargo proteins of the endosomal SNX-BAR sorting complex ... [more]
Proc Natl Acad Sci U S A Jun. 21, 2022; 119(25);e2201980119 [Pubmed: 35696571]
Throughput
- High Throughput
Curated By
- BioGRID