BAIT
TGOLN2
TGN38, TGN46, TGN48, TGN51, TTGN2
trans-golgi network protein 2
GO Process (0)
GO Function (1)
GO Component (4)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HMOX1
HMOX1D, HO-1, HSP32, bK286B10, CTA-286B10.6
heme oxygenase (decycling) 1
GO Process (31)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- angiogenesis [TAS]
- cell death [ISS]
- cellular iron ion homeostasis [TAS]
- cellular response to hypoxia [IEP]
- endothelial cell proliferation [TAS]
- erythrocyte homeostasis [IMP]
- excretion [IC]
- heme catabolic process [IDA, TAS]
- heme oxidation [IDA]
- intracellular signal transduction [TAS]
- iron ion homeostasis [IDA, IMP]
- low-density lipoprotein particle clearance [TAS]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- negative regulation of leukocyte migration [TAS]
- negative regulation of smooth muscle cell proliferation [IDA]
- porphyrin-containing compound metabolic process [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of chemokine biosynthetic process [TAS]
- positive regulation of smooth muscle cell proliferation [IDA]
- positive regulation of vasodilation [IC]
- protein homooligomerization [IDA]
- regulation of angiogenesis [TAS]
- regulation of sequence-specific DNA binding transcription factor activity [ISS]
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress [ISS]
- response to hydrogen peroxide [ISS]
- response to nicotine [IDA]
- response to oxidative stress [IMP]
- small molecule metabolic process [TAS]
- smooth muscle hyperplasia [TAS]
- transmembrane transport [TAS]
- wound healing involved in inflammatory response [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.
Endosomal sorting maintains cellular homeostasis by recycling transmembrane proteins and associated proteins and lipids (termed "cargoes") from the endosomal network to multiple subcellular destinations, including retrograde traffic to the trans-Golgi network (TGN). Viral and bacterial pathogens subvert retrograde trafficking machinery to facilitate infectivity. Here, we develop a proteomic screen to identify retrograde cargo proteins of the endosomal SNX-BAR sorting complex ... [more]
Proc Natl Acad Sci U S A Jun. 21, 2022; 119(25);e2201980119 [Pubmed: 35696571]
Throughput
- High Throughput
Curated By
- BioGRID