BAIT
TGOLN2
TGN38, TGN46, TGN48, TGN51, TTGN2
trans-golgi network protein 2
GO Process (0)
GO Function (1)
GO Component (4)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
FURIN
FUR, PACE, PCSK3, SPC1
furin (paired basic amino acid cleaving enzyme)
GO Process (29)
GO Function (7)
GO Component (10)
Gene Ontology Biological Process
- Notch signaling pathway [TAS]
- cell proliferation [IMP]
- cellular protein metabolic process [TAS]
- collagen catabolic process [TAS]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- negative regulation of endopeptidase activity [IDA]
- negative regulation of low-density lipoprotein particle receptor catabolic process [IDA]
- negative regulation of nerve growth factor production [IDA]
- negative regulation of transforming growth factor beta1 production [IMP]
- nerve growth factor processing [TAS]
- nerve growth factor production [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptide biosynthetic process [IDA]
- peptide hormone processing [IDA]
- peptidyl-glutamic acid carboxylation [TAS]
- positive regulation of membrane protein ectodomain proteolysis [IC]
- post-translational protein modification [TAS]
- protein processing [IDA, IMP]
- proteolysis [TAS]
- regulation of endopeptidase activity [IDA]
- regulation of protein catabolic process [IMP]
- secretion by cell [IDA]
- signal peptide processing [IDA]
- transforming growth factor beta receptor signaling pathway [TAS]
- viral life cycle [IEP]
- viral process [TAS]
- viral protein processing [TAS]
- virion assembly [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.
Endosomal sorting maintains cellular homeostasis by recycling transmembrane proteins and associated proteins and lipids (termed "cargoes") from the endosomal network to multiple subcellular destinations, including retrograde traffic to the trans-Golgi network (TGN). Viral and bacterial pathogens subvert retrograde trafficking machinery to facilitate infectivity. Here, we develop a proteomic screen to identify retrograde cargo proteins of the endosomal SNX-BAR sorting complex ... [more]
Proc Natl Acad Sci U S A Jun. 21, 2022; 119(25);e2201980119 [Pubmed: 35696571]
Throughput
- High Throughput
Curated By
- BioGRID