BAIT
TGOLN2
TGN38, TGN46, TGN48, TGN51, TTGN2
trans-golgi network protein 2
GO Process (0)
GO Function (1)
GO Component (4)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
LRP4
CLSS, LRP-4, LRP10, MEGF7, SOST2
low density lipoprotein receptor-related protein 4
GO Process (14)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
- dendrite morphogenesis [ISS]
- extracellular matrix organization [TAS]
- kidney development [IDA]
- limb development [IDA]
- negative regulation of axonogenesis [ISS]
- negative regulation of canonical Wnt signaling pathway [IDA, IMP]
- negative regulation of ossification [IMP]
- positive regulation of presynaptic membrane organization [ISS]
- postsynaptic membrane assembly [ISS]
- presynaptic membrane assembly [ISS]
- protein heterotetramerization [ISS]
- skeletal muscle acetylcholine-gated channel clustering [ISS]
- synapse organization [ISS]
- synaptic growth at neuromuscular junction [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.
Endosomal sorting maintains cellular homeostasis by recycling transmembrane proteins and associated proteins and lipids (termed "cargoes") from the endosomal network to multiple subcellular destinations, including retrograde traffic to the trans-Golgi network (TGN). Viral and bacterial pathogens subvert retrograde trafficking machinery to facilitate infectivity. Here, we develop a proteomic screen to identify retrograde cargo proteins of the endosomal SNX-BAR sorting complex ... [more]
Proc Natl Acad Sci U S A Jun. 21, 2022; 119(25);e2201980119 [Pubmed: 35696571]
Throughput
- High Throughput
Curated By
- BioGRID