BAIT
TGOLN2
TGN38, TGN46, TGN48, TGN51, TTGN2
trans-golgi network protein 2
GO Process (0)
GO Function (1)
GO Component (4)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
FAP
DPPIV, FAPA, SIMP
fibroblast activation protein, alpha
GO Process (13)
GO Function (11)
GO Component (8)
Gene Ontology Biological Process
- endothelial cell migration [IDA]
- melanocyte apoptotic process [ISS]
- melanocyte proliferation [ISS]
- mitotic cell cycle arrest [ISS]
- negative regulation of cell proliferation involved in contact inhibition [ISS]
- negative regulation of extracellular matrix disassembly [IDA]
- negative regulation of extracellular matrix organization [IDA]
- positive regulation of cell cycle arrest [ISS]
- positive regulation of execution phase of apoptosis [ISS]
- proteolysis [IDA]
- proteolysis involved in cellular protein catabolic process [IDA]
- regulation of collagen catabolic process [IDA]
- regulation of fibrinolysis [IC]
Gene Ontology Molecular Function- dipeptidyl-peptidase activity [IDA, NAS]
- endopeptidase activity [IDA]
- integrin binding [IPI]
- metalloendopeptidase activity [TAS]
- peptidase activity [IDA]
- protease binding [IPI]
- protein binding [IPI]
- protein dimerization activity [NAS]
- protein homodimerization activity [IDA, NAS]
- serine-type endopeptidase activity [IDA]
- serine-type peptidase activity [IDA, IMP, NAS]
- dipeptidyl-peptidase activity [IDA, NAS]
- endopeptidase activity [IDA]
- integrin binding [IPI]
- metalloendopeptidase activity [TAS]
- peptidase activity [IDA]
- protease binding [IPI]
- protein binding [IPI]
- protein dimerization activity [NAS]
- protein homodimerization activity [IDA, NAS]
- serine-type endopeptidase activity [IDA]
- serine-type peptidase activity [IDA, IMP, NAS]
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.
Endosomal sorting maintains cellular homeostasis by recycling transmembrane proteins and associated proteins and lipids (termed "cargoes") from the endosomal network to multiple subcellular destinations, including retrograde traffic to the trans-Golgi network (TGN). Viral and bacterial pathogens subvert retrograde trafficking machinery to facilitate infectivity. Here, we develop a proteomic screen to identify retrograde cargo proteins of the endosomal SNX-BAR sorting complex ... [more]
Proc Natl Acad Sci U S A Jun. 21, 2022; 119(25);e2201980119 [Pubmed: 35696571]
Throughput
- High Throughput
Curated By
- BioGRID