BAIT
TGOLN2
TGN38, TGN46, TGN48, TGN51, TTGN2
trans-golgi network protein 2
GO Process (0)
GO Function (1)
GO Component (4)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PKD2
APKD2, PC2, PKD4, Pc-2, TRPP2
polycystic kidney disease 2 (autosomal dominant)
GO Process (48)
GO Function (17)
GO Component (19)
Gene Ontology Biological Process
- JAK-STAT cascade [ISS]
- aorta development [IEP]
- branching involved in ureteric bud morphogenesis [IEP]
- calcium ion transmembrane transport [IDA]
- calcium ion transport [IDA, ISS]
- cell cycle arrest [ISS]
- cellular response to fluid shear stress [IMP]
- cellular response to hydrostatic pressure [IDA]
- cellular response to osmotic stress [IDA]
- cellular response to reactive oxygen species [NAS]
- centrosome duplication [NAS]
- cytoplasmic sequestering of transcription factor [IMP]
- detection of mechanical stimulus [IBA, ISS]
- detection of nodal flow [ISS]
- determination of left/right symmetry [ISS]
- determination of liver left/right asymmetry [IMP]
- embryonic placenta development [ISS]
- heart development [IEP]
- heart looping [IMP]
- liver development [IEP]
- mesonephric duct development [IEP]
- mesonephric tubule development [IEP]
- metanephric S-shaped body morphogenesis [IEP]
- metanephric ascending thin limb development [IEP]
- metanephric cortex development [IEP]
- metanephric cortical collecting duct development [IEP]
- metanephric distal tubule development [IEP]
- metanephric mesenchyme development [IEP]
- metanephric part of ureteric bud development [IEP]
- metanephric smooth muscle tissue development [IEP]
- negative regulation of G1/S transition of mitotic cell cycle [IMP]
- negative regulation of cell proliferation [NAS]
- negative regulation of ryanodine-sensitive calcium-release channel activity [ISS]
- neural tube development [IEP]
- placenta blood vessel development [ISS]
- positive regulation of cell cycle arrest [IMP]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [IDA]
- positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [IMP]
- positive regulation of nitric oxide biosynthetic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- regulation of cAMP metabolic process [ISS]
- regulation of calcium ion import [IDA]
- regulation of cell proliferation [IMP]
- release of sequestered calcium ion into cytosol [IDA, IMP]
- renal artery morphogenesis [IEP]
- renal tubule morphogenesis [ISS]
- sodium ion transmembrane transport [IDA]
- spinal cord development [IEP]
Gene Ontology Molecular Function- ATPase binding [ISS]
- HLH domain binding [IPI]
- actinin binding [IDA]
- calcium ion binding [ISS]
- calcium-induced calcium release activity [IDA]
- cytoskeletal protein binding [IDA]
- identical protein binding [IPI, ISS]
- ion channel binding [IPI]
- phosphoprotein binding [IPI]
- potassium channel activity [ISS]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- receptor binding [IPI]
- voltage-gated calcium channel activity [IDA]
- voltage-gated cation channel activity [IDA]
- voltage-gated ion channel activity [IDA]
- voltage-gated sodium channel activity [IDA]
- ATPase binding [ISS]
- HLH domain binding [IPI]
- actinin binding [IDA]
- calcium ion binding [ISS]
- calcium-induced calcium release activity [IDA]
- cytoskeletal protein binding [IDA]
- identical protein binding [IPI, ISS]
- ion channel binding [IPI]
- phosphoprotein binding [IPI]
- potassium channel activity [ISS]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- receptor binding [IPI]
- voltage-gated calcium channel activity [IDA]
- voltage-gated cation channel activity [IDA]
- voltage-gated ion channel activity [IDA]
- voltage-gated sodium channel activity [IDA]
Gene Ontology Cellular Component
- basal cortex [IDA]
- basal plasma membrane [IDA]
- cell-cell junction [ISS]
- ciliary basal body [IDA]
- cilium [ISS]
- cytoplasm [IDA, IMP]
- endoplasmic reticulum [IDA, IMP]
- endoplasmic reticulum membrane [IDA]
- extracellular vesicular exosome [IDA]
- filamentous actin [IDA]
- integral component of cytoplasmic side of endoplasmic reticulum membrane [IDA]
- integral component of lumenal side of endoplasmic reticulum membrane [IDA]
- integral component of plasma membrane [IDA]
- lamellipodium [IDA]
- mitotic spindle [IDA]
- motile primary cilium [ISS]
- nonmotile primary cilium [ISS]
- plasma membrane [IDA]
- polycystin complex [ISS]
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.
Endosomal sorting maintains cellular homeostasis by recycling transmembrane proteins and associated proteins and lipids (termed "cargoes") from the endosomal network to multiple subcellular destinations, including retrograde traffic to the trans-Golgi network (TGN). Viral and bacterial pathogens subvert retrograde trafficking machinery to facilitate infectivity. Here, we develop a proteomic screen to identify retrograde cargo proteins of the endosomal SNX-BAR sorting complex ... [more]
Proc Natl Acad Sci U S A Jun. 21, 2022; 119(25);e2201980119 [Pubmed: 35696571]
Throughput
- High Throughput
Curated By
- BioGRID