BAIT
TGOLN2
TGN38, TGN46, TGN48, TGN51, TTGN2
trans-golgi network protein 2
GO Process (0)
GO Function (1)
GO Component (4)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ABCA7
ABCA-SSN, ABCX
ATP-binding cassette, sub-family A (ABC1), member 7
GO Process (20)
GO Function (3)
GO Component (8)
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- apolipoprotein A-I-mediated signaling pathway [IDA]
- cholesterol efflux [IDA]
- high-density lipoprotein particle assembly [IDA]
- memory [ISS]
- negative regulation of ATPase activity [IDA]
- negative regulation of amyloid precursor protein biosynthetic process [ISS]
- negative regulation of beta-amyloid formation [ISS]
- peptide cross-linking [ISS]
- phospholipid efflux [IDA]
- phospholipid scrambling [IDA]
- positive regulation of ATPase activity [IDA]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of beta-amyloid clearance [ISS]
- positive regulation of cholesterol efflux [ISS]
- positive regulation of engulfment of apoptotic cell [ISS]
- positive regulation of phagocytosis [ISS]
- positive regulation of phospholipid efflux [ISS]
- protein localization to nucleus [ISS]
- transmembrane transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.
Endosomal sorting maintains cellular homeostasis by recycling transmembrane proteins and associated proteins and lipids (termed "cargoes") from the endosomal network to multiple subcellular destinations, including retrograde traffic to the trans-Golgi network (TGN). Viral and bacterial pathogens subvert retrograde trafficking machinery to facilitate infectivity. Here, we develop a proteomic screen to identify retrograde cargo proteins of the endosomal SNX-BAR sorting complex ... [more]
Proc Natl Acad Sci U S A Jun. 21, 2022; 119(25);e2201980119 [Pubmed: 35696571]
Throughput
- High Throughput
Curated By
- BioGRID