BAIT
TGOLN2
TGN38, TGN46, TGN48, TGN51, TTGN2
trans-golgi network protein 2
GO Process (0)
GO Function (1)
GO Component (4)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
FLCN
BHD, FLCL
folliculin
GO Process (28)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- TOR signaling [IMP]
- cell-cell junction assembly [ISS]
- hemopoiesis [ISS]
- in utero embryonic development [ISS]
- negative regulation of ATP biosynthetic process [ISS]
- negative regulation of ERK1 and ERK2 cascade [ISS]
- negative regulation of Rho protein signal transduction [IMP]
- negative regulation of TOR signaling [ISS]
- negative regulation of cell growth [IDA]
- negative regulation of cell migration [IMP]
- negative regulation of cell proliferation involved in kidney development [ISS]
- negative regulation of energy homeostasis [ISS]
- negative regulation of gene expression [ISS]
- negative regulation of mitochondrion organization [ISS]
- negative regulation of protein kinase B signaling [ISS]
- negative regulation of protein localization to nucleus [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of TOR signaling [ISS]
- positive regulation of apoptotic process [ISS]
- positive regulation of cell adhesion [IMP]
- positive regulation of protein phosphorylation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transforming growth factor beta receptor signaling pathway [IDA, ISS]
- regulation of TOR signaling [ISS]
- regulation of cytokinesis [IMP]
- regulation of histone acetylation [ISS]
- regulation of pro-B cell differentiation [ISS]
- regulation of protein phosphorylation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.
Endosomal sorting maintains cellular homeostasis by recycling transmembrane proteins and associated proteins and lipids (termed "cargoes") from the endosomal network to multiple subcellular destinations, including retrograde traffic to the trans-Golgi network (TGN). Viral and bacterial pathogens subvert retrograde trafficking machinery to facilitate infectivity. Here, we develop a proteomic screen to identify retrograde cargo proteins of the endosomal SNX-BAR sorting complex ... [more]
Proc Natl Acad Sci U S A Jun. 21, 2022; 119(25);e2201980119 [Pubmed: 35696571]
Throughput
- High Throughput
Curated By
- BioGRID