An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.

Publication

HDLBP-stabilized lncFAL inhibits ferroptosis vulnerability by diminishing Trim69-dependent FSP1 degradation in hepatocellular carcinoma.

Yuan J, Lv T, Yang J, Wu Z, Yan L, Yang J, Shi Y

Recent studies have suggested that exploring the potential mechanisms regulating ferroptosis vulnerability may contribute to improving the systemic therapeutic efficacy in HCC. High-density lipoprotein-binding protein (HDLBP), the largest RNA-binding protein, is an important transporter that protects cells from overaccumulation of cholesterol, but few studies have elucidated the role of HDLBP in the regulation of ferroptosis vulnerability in HCC. Our study ... [more]

Redox Biol Dec. 01, 2022; 58();102546 [Pubmed: 36423520]

Throughput

Low Throughput

Additional Notes

Hit is NONHSAG111059.1/lncFAL derived from PLXNB2 gene

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
PLXNB2 HDLBP	Protein-RNA Protein-RNA An interaction is detected between and protein and an RNA in vitro.	Yuan J (2022)	Low	-	BioGRID	3565061

Curated By

BioGRID

Interaction Summary

HDLBP

Gene Ontology Molecular Function

lipid binding [TAS]poly(A) RNA binding [IDA]protein binding [IPI]

Gene Ontology Cellular Component

PLXNB2

Gene Ontology Biological Process

Gene Ontology Molecular Function

protein binding [IPI]semaphorin receptor activity [ISS]