BAIT
CEBPG
C/EBP[g], C/EBPgamma, GPE1-BP, Gpe1bp, Ig/EBP
CCAAT/enhancer binding protein (C/EBP), gamma
GO Process (13)
GO Function (10)
GO Component (2)
Gene Ontology Biological Process
- chromatin remodeling [TAS]
- enucleate erythrocyte differentiation [IMP]
- immune response [IDA]
- mRNA metabolic process [IMP]
- natural killer cell mediated cytotoxicity [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- nucleosome disassembly [TAS]
- positive regulation of DNA repair [ISS]
- positive regulation of interferon-gamma biosynthetic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of transcription, DNA-templated [IDA]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- double-stranded DNA binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [NAS]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [ISO, ISS]
- DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- double-stranded DNA binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [NAS]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [ISO, ISS]
Gene Ontology Cellular Component
- nucleoplasm [ISO]
- nucleus [IDA]
Mus musculus
PREY
DDIT3
CHOP-10, CHOP10, chop, gadd153
DNA-damage inducible transcript 3
GO Process (28)
GO Function (8)
GO Component (8)
Gene Ontology Biological Process
- ER overload response [IMP, ISO]
- apoptotic process [IMP]
- blood vessel maturation [IMP]
- cell redox homeostasis [ISO]
- endoplasmic reticulum unfolded protein response [IMP]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [IMP, ISO]
- mRNA transcription from RNA polymerase II promoter [ISO]
- negative regulation of CREB transcription factor activity [ISO]
- negative regulation of canonical Wnt signaling pathway [IDA]
- negative regulation of determination of dorsal identity [IDA, ISO]
- negative regulation of fat cell differentiation [IGI]
- negative regulation of myoblast differentiation [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [IDA, IMP, ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of interleukin-8 production [ISO]
- positive regulation of neuron apoptotic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- regulation of transcription involved in anterior/posterior axis specification [IDA]
- regulation of transcription, DNA-templated [IMP, ISO]
- release of sequestered calcium ion into cytosol [IMP]
- response to endoplasmic reticulum stress [IDA, ISO]
- response to starvation [IDA]
- response to unfolded protein [ISO]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IMP, ISO]
- transcription factor binding [ISO]
- DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IMP, ISO]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
- CHOP-C/EBP complex [ISO]
- cell [IMP]
- cytoplasm [ISO]
- cytosol [IMP]
- intracellular [IMP]
- late endosome [IDA]
- nucleoplasm [ISO]
- nucleus [IC, IDA, ISO]
Mus musculus
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells.
Regulatory programs governing neuronal death and axon regeneration in neurodegenerative diseases remain poorly understood. In adult mice, optic nerve crush (ONC) injury by severing retinal ganglion cell (RGC) axons results in massive RGC death and regenerative failure. We performed an in vivo CRISPR-Cas9-based genome-wide screen of 1,893 transcription factors (TFs) to seek repressors of RGC survival and axon regeneration following ONC. ... [more]
Neuron Aug. 17, 2022; 110(16);2607-2624.e8 [Pubmed: 35767995]
Throughput
- Low Throughput
Ontology Terms
- phenotype: retinal ganglion cell degeneration (MP:0008067)
Additional Notes
- co-knockout of these TFs protect most retinal ganglion cell (RGC) types from injury-induced degeneration
Curated By
- BioGRID