BAIT
ZBTB18
C2H2-171, MRD22, RP58, TAZ-1, ZNF238
zinc finger and BTB domain containing 18
GO Process (3)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GSTP1
DFN7, FAEES3, GST3, GSTP, HEL-S-22, PI
glutathione S-transferase pi 1
GO Process (30)
GO Function (7)
GO Component (9)
Gene Ontology Biological Process
- cellular response to lipopolysaccharide [ISS]
- central nervous system development [TAS]
- common myeloid progenitor cell proliferation [ISS]
- glutathione derivative biosynthetic process [TAS]
- glutathione metabolic process [IDA]
- negative regulation of ERK1 and ERK2 cascade [IDA]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [ISS]
- negative regulation of JUN kinase activity [IDA]
- negative regulation of MAP kinase activity [IDA]
- negative regulation of MAPK cascade [NAS]
- negative regulation of acute inflammatory response [NAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of biosynthetic process [IDA]
- negative regulation of extrinsic apoptotic signaling pathway [IDA]
- negative regulation of fibroblast proliferation [ISS]
- negative regulation of interleukin-1 beta production [IDA]
- negative regulation of leukocyte proliferation [ISS]
- negative regulation of monocyte chemotactic protein-1 production [IDA]
- negative regulation of nitric-oxide synthase biosynthetic process [IDA]
- negative regulation of protein kinase activity [IDA]
- negative regulation of stress-activated MAPK cascade [ISS]
- negative regulation of tumor necrosis factor production [IDA]
- negative regulation of tumor necrosis factor-mediated signaling pathway [IC]
- nitric oxide storage [NAS]
- positive regulation of superoxide anion generation [ISS]
- regulation of ERK1 and ERK2 cascade [ISS]
- regulation of stress-activated MAPK cascade [ISS]
- response to reactive oxygen species [ISS]
- small molecule metabolic process [TAS]
- xenobiotic metabolic process [IDA, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ZBTB18 inhibits SREBP-dependent lipid synthesis by halting CTBPs and LSD1 activity in glioblastoma.
Enhanced fatty acid synthesis is a hallmark of tumors, including glioblastoma. SREBF1/2 regulate the expression of enzymes involved in fatty acid and cholesterol synthesis. Yet, little is known about the precise mechanism regulating SREBP gene expression in glioblastoma. Here, we show that a novel interaction between the co-activator/co-repressor CTBP and the tumor suppressor ZBTB18 regulates the expression of SREBP genes. ... [more]
Life Sci Alliance Jan. 01, 2023; 6(1); [Pubmed: 36414381]
Throughput
- High Throughput
Curated By
- BioGRID