BAIT
ATG16L1
APG16L, ATG16A, ATG16L, IBD10, WDR30, hCG_1817841
autophagy related 16-like 1 (S. cerevisiae)
GO Process (3)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CXADR
CAR, CAR4/6, HCAR
coxsackie virus and adenovirus receptor
GO Process (17)
GO Function (8)
GO Component (19)
Gene Ontology Biological Process
- AV node cell to bundle of His cell communication [ISS]
- actin cytoskeleton reorganization [IDA]
- blood coagulation [TAS]
- cardiac muscle fiber development [ISS]
- cell-cell junction organization [ISS]
- defense response to virus [IDA]
- epithelial structure maintenance [IMP]
- gamma-delta T cell activation [ISS]
- germ cell migration [ISS]
- heart development [ISS]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [IDA]
- homotypic cell-cell adhesion [IDA]
- leukocyte migration [TAS]
- mitochondrion organization [ISS]
- neutrophil chemotaxis [IMP]
- regulation of immune response [TAS]
- transepithelial transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- acrosomal vesicle [ISS]
- adherens junction [IDA]
- apicolateral plasma membrane [IDA]
- basolateral plasma membrane [IDA]
- cell body [ISS]
- cell junction [IDA]
- cell-cell junction [IDA]
- extracellular space [IDA]
- filopodium [ISS]
- growth cone [ISS]
- integral component of plasma membrane [NAS]
- intercalated disc [IDA]
- membrane raft [IDA]
- neuromuscular junction [IDA]
- neuron projection [ISS]
- nucleoplasm [IDA]
- plasma membrane [IDA, TAS]
- protein complex [IDA]
- tight junction [IDA]
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Pulse-SILAC and interactomics reveal distinct DDB1-CUL4 associated factors (DCAFs), cellular functions, and protein substrates.
Cullin-RING finger ligases (CRLs) represent the largest family of ubiquitin ligases. They are responsible for the ubiquitination of ?20% of cellular proteins degraded through the proteasome, by catalyzing the transfer of E2-loaded ubiquitin to a substrate. Seven Cullins are described in vertebrates. Among them, CUL4 associates with DDB1 to form the CUL4-DDB1 ubiquitin ligase complex, which is involved in protein ... [more]
Mol Cell Proteomics Sep. 07, 2023; ();100644 [Pubmed: 37689310]
Throughput
- High Throughput
Additional Notes
- BioID
Curated By
- BioGRID