BAIT
LRP8
APOER2, HSZ75190, LRP-8, MCI1, RP5-1024G6.8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
GO Process (18)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
- ammon gyrus development [ISS]
- blood coagulation [TAS]
- cytokine-mediated signaling pathway [NAS]
- endocytosis [IDA]
- lipid metabolic process [NAS]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- phototransduction, visible light [TAS]
- positive regulation of CREB transcription factor activity [ISS]
- positive regulation of dendrite development [ISS]
- positive regulation of dendritic spine morphogenesis [ISS]
- positive regulation of peptidyl-tyrosine phosphorylation [ISS]
- positive regulation of protein tyrosine kinase activity [ISS]
- proteolysis [NAS]
- receptor-mediated endocytosis [IDA]
- reelin-mediated signaling pathway [ISS]
- regulation of synaptic transmission [ISS]
- retinoid metabolic process [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SLC7A11
CCBR1, xCT
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
GO Process (7)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
LRP8-mediated selenocysteine uptake is a targetable vulnerability in MYCN-amplified neuroblastoma.
Ferroptosis has emerged as an attractive strategy in cancer therapy. Understanding the operational networks regulating ferroptosis may unravel vulnerabilities that could be harnessed for therapeutic benefit. Using CRISPR-activation screens in ferroptosis hypersensitive cells, we identify the selenoprotein P (SELENOP) receptor, LRP8, as a key determinant protecting MYCN-amplified neuroblastoma cells from ferroptosis. Genetic deletion of LRP8 leads to ferroptosis as a ... [more]
EMBO Mol Med Jul. 12, 2023; ();e18014 [Pubmed: 37435859]
Throughput
- Low Throughput
Additional Notes
- CRISPR-based genetic interaction
Curated By
- BioGRID