BAIT

DET1

de-etiolated homolog 1 (Arabidopsis)
UPS Project
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY

CAPZA2

CAPPA2, CAPZ
capping protein (actin filament) muscle Z-line, alpha 2
GO Process (4)
GO Function (0)
GO Component (4)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Homo sapiens

Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

Publication

Pulse-SILAC and interactomics reveal distinct DDB1-CUL4 associated factors (DCAFs), cellular functions, and protein substrates.

Raisch J, Dubois ML, Groleau M, Levesque D, Burger T, Jurkovic CM, Brailly R, Marbach G, McKenna A, Barrette C, Jacques P E, Boisvert FM

Cullin-RING finger ligases (CRLs) represent the largest family of ubiquitin ligases. They are responsible for the ubiquitination of ?20% of cellular proteins degraded through the proteasome, by catalyzing the transfer of E2-loaded ubiquitin to a substrate. Seven Cullins are described in vertebrates. Among them, CUL4 associates with DDB1 to form the CUL4-DDB1 ubiquitin ligase complex, which is involved in protein ... [more]

Mol Cell Proteomics Sep. 07, 2023; ();100644 [Pubmed: 37689310]

Throughput

  • High Throughput

Additional Notes

  • BioID

Curated By

  • BioGRID