BAIT
GNB2
guanine nucleotide binding protein (G protein), beta polypeptide 2
GO Process (6)
GO Function (4)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
WNK2
NY-CO-43, P/OKcl.13, PRKWNK2, SDCCAG43, RP11-165J3.2
WNK lysine deficient protein kinase 2
GO Process (7)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- intracellular signal transduction [ISS]
- negative regulation of ERK1 and ERK2 cascade [IMP]
- negative regulation of cell proliferation [IMP]
- positive regulation of sodium ion transmembrane transporter activity [IMP]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA]
- regulation of ion homeostasis [IMP]
Gene Ontology Molecular Function
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Pulse-SILAC and interactomics reveal distinct DDB1-CUL4 associated factors (DCAFs), cellular functions, and protein substrates.
Cullin-RING finger ligases (CRLs) represent the largest family of ubiquitin ligases. They are responsible for the ubiquitination of ?20% of cellular proteins degraded through the proteasome, by catalyzing the transfer of E2-loaded ubiquitin to a substrate. Seven Cullins are described in vertebrates. Among them, CUL4 associates with DDB1 to form the CUL4-DDB1 ubiquitin ligase complex, which is involved in protein ... [more]
Mol Cell Proteomics Sep. 07, 2023; ();100644 [Pubmed: 37689310]
Throughput
- High Throughput
Additional Notes
- BioID
Curated By
- BioGRID