BAIT
GNB2
guanine nucleotide binding protein (G protein), beta polypeptide 2
GO Process (6)
GO Function (4)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
NAMPT
1110035O14Rik, PBEF, PBEF1, VF, VISFATIN
nicotinamide phosphoribosyltransferase
GO Process (13)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
- NAD metabolic process [TAS]
- adipose tissue development [IDA]
- cell-cell signaling [TAS]
- circadian regulation of gene expression [ISS]
- insulin receptor signaling pathway [IDA]
- nicotinamide metabolic process [TAS]
- positive regulation of cell proliferation [TAS]
- positive regulation of nitric-oxide synthase biosynthetic process [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
- vitamin metabolic process [TAS]
- water-soluble vitamin metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Pulse-SILAC and interactomics reveal distinct DDB1-CUL4 associated factors (DCAFs), cellular functions, and protein substrates.
Cullin-RING finger ligases (CRLs) represent the largest family of ubiquitin ligases. They are responsible for the ubiquitination of ?20% of cellular proteins degraded through the proteasome, by catalyzing the transfer of E2-loaded ubiquitin to a substrate. Seven Cullins are described in vertebrates. Among them, CUL4 associates with DDB1 to form the CUL4-DDB1 ubiquitin ligase complex, which is involved in protein ... [more]
Mol Cell Proteomics Sep. 07, 2023; ();100644 [Pubmed: 37689310]
Throughput
- High Throughput
Additional Notes
- BioID
Curated By
- BioGRID