BAIT
RFWD2
COP1, RNF200, RP11-318C24.3
ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
GO Process (3)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RAB3GAP1
P130, RAB3GAP, RAB3GAP130, WARBM1
RAB3 GTPase activating protein subunit 1 (catalytic)
GO Process (14)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- brain development [IMP]
- camera-type eye development [IMP]
- establishment of protein localization to endoplasmic reticulum membrane [IMP]
- face morphogenesis [IMP]
- hypothalamus development [IMP]
- lipid particle organization [IMP]
- positive regulation of GTP catabolic process [IMP]
- positive regulation of Rab GTPase activity [IMP, ISS]
- positive regulation of endoplasmic reticulum tubular network organization [IMP]
- positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization [ISS]
- regulation of GTPase activity [IDA]
- regulation of calcium ion-dependent exocytosis of neurotransmitter [ISS]
- regulation of excitatory postsynaptic membrane potential [ISS]
- regulation of short-term neuronal synaptic plasticity [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Pulse-SILAC and interactomics reveal distinct DDB1-CUL4 associated factors (DCAFs), cellular functions, and protein substrates.
Cullin-RING finger ligases (CRLs) represent the largest family of ubiquitin ligases. They are responsible for the ubiquitination of ?20% of cellular proteins degraded through the proteasome, by catalyzing the transfer of E2-loaded ubiquitin to a substrate. Seven Cullins are described in vertebrates. Among them, CUL4 associates with DDB1 to form the CUL4-DDB1 ubiquitin ligase complex, which is involved in protein ... [more]
Mol Cell Proteomics Sep. 07, 2023; ();100644 [Pubmed: 37689310]
Throughput
- High Throughput
Additional Notes
- BioID
Curated By
- BioGRID